Sunday, June 30, 2013

The thing about Nate Silver


I know, I know, I hear you now: “go find your own favorite statistician!” The thing is, Nate Silver is not only brilliant with numbers, but he also has thoughtful, well-developed ideas and he articulates them well.1 Silver knows his stuff, and he makes it fun to learn about. If you haven’t read any of his blogs or his book2, you are in for a treat. He gets me all riled up about the fact that we have some much information yet so little knowledge. He’ll get you excited about figuring out how to make sense of heaps of data. He’ll show you how awesome numbers are.

It’s like math orgasm.



Obviously Nate gets lots of bonus points for being not only a numbers guy but ALSO a words guy. In the intro to his book, he talks you through the etymology of “prediction” (Latin roots, with a superstition-kinda-fortune-telling connotation) and “forecast” (Germanic roots, implying prudent planning despite uncertain conditions). Forecasting is definitely progress, when that is actually what we are doing, since it means using what we already have to make more educated guesses. And yet, we’re still addicted to prediction, even though we’re embarrassingly inept.

I wonder if part of what will make us better forecasters is recognizing how biased our predictions are by our own confidence. As Silver puts it, “Human beings have an extraordinary capacity to ignore risks that threaten their livelihood, as though this will make them go away.” We all do it, and to a large extent I think this can be a positive thing. I mean, let’s face it, if we really stopped to think about every last obstacle that could possibly derail our plans, it would be much more difficult to get up with a smile each day. It’s nice to feel able and self-sufficient, and there is good evidence that those who approach tasks – intellectual or athletic ones – with confidence are those who often end up more successful. No one likes arrogance, though, and it’s a fine line that divides the confident from the arrogant.




Nate comments at one point that “most of our strengths and weaknesses as a nation – our ingenuity and our industriousness, our arrogance and our impatience – stem from our unshakable belief in the idea that we choose our own course.” And we should be better at controlling our fate in this data-rich era, right? Maybe not.

“We think we want information when we really want knowledge.”

With modern technology, we have access to more, but unfortunately “if the quantity of information is increasing by 2.5 quintillion bytes per day, the amount of useful information almost certainly isn’t. Most of it is just noise, and the noise is increasing faster than the signal. There are so many hypotheses to test, so many data sets to mine – but a relatively constant amount of objective truth.” Last week, we talked a bit in our summer journal club about the possibility of completely “null fields”; this is the idea that there are whole branches3 of science in which we are looking for relationships that simply don’t exist. It’s a big question, to be sure, and the distinction between statistical significance and genuine relevance is of obvious importance. We’re a bunch of twenty-something-year-olds talking through this stuff, and we’re not quite presumptuous enough to come to any conclusions, but it’s interesting to think about.




Another major issue we’re up against is the necessity for building assumptions into our models. A question as simple as “are these events independent or not?” can change your whole analysis of risk. Mathematically, it becomes obvious right away what a dramatic difference the extent of the dependence can make4. In the real world, we don’t always know if the events are independent or not; further, even when we know they’re not independent it’s pretty difficult to quantify how related they are. “Risk” is the stuff that’s quantifiable: “I have a 1/20 chance of selecting the blue.” Uncertainty, though, is the risk that is hard to measure. When we build models and forget to admit just how much uncertainty there really is, we end up forecasting in a range that might be too narrow. It’s tricky to keep track of the difference between what we know and what we think we know, seeing as we don’t know which is which. This partially explains why we have a nasty habit of making predictions that are absurdly precise but not at all accurate.



Too often, we convince ourselves that certain bad outcomes are simply not possible. Let’s remember what Douglas Adams said in The Hitchhiker’s Guide to the Galaxy: “The major difference between a thing that might go wrong and a thing than cannot possibly go wrong is that when a thing that cannot possibly go wrong goes wrong it usually turns out to be impossible to get at or repair.”

So…that’s that for today. I’m pretty excited about math, I think staying humble makes us better forecasters, and I’m curious to hear what you think about statistics in the Real World! 


1 That last part, that part about expressing them...it’s not trivial. No one really wants to talk to a mathematician or a scientist who speaks their own language and can’t use normal words.
2 In 2012, Silver published his first book, The Signal and the Noise: Why So Many Predictions Fail – But Some Don’t, and he currently writes the blog FiveThirtyEight as part of The New York Times, available at http://fivethirtyeight.blogs.nytimes.com; unless otherwise noted, quotes in this post are from his book.
3 or sub-disciplines of sub-branches or whatever…don’t want to offend anyone
4 If you have independent events, you simply multiply the probability of each event occurring to find the probability that they all occur simultaneously, i.e. P(A and B and C) = P(A)*P(B)*P(C). However, if the occurrence of some of the events depends on the others, you have to know how likely the second event is to occur given that the first already has, i.e. P(A and B) = P(A)*P(B|A). There are lots of great examples we could talk about using anything from economics to medical diagnosis, but you already get the idea.

Thursday, June 13, 2013

“You learn to ice skate in the summer and you learn to swim in the winter.”




One dichotomy that makes many fields particularly challenging is the dichotomy between the generalist and the expert…and the simple fact that you sort of need to be both1. As a practicing physician, you should know something about everything and everything about something – that is, you need to know all the basics of human physiology, and then try to know basically everything about your particular clinical specialty. Even if you are destined to become a brilliant brain surgeon, you should still understand the gastrointestinal system, right?

I think medical students sometimes feel caught in the middle. It’s not always clear how detailed to get or how broad to let yourself go. For instance, in learning biochemical pathways, we don’t delve into all the structures and electron exchanging involved, so we are certainly not discussing nitty-gritty details2. Neither, though, do we get waaaaay broad and tackle how the disease affects an individual’s livelihood, let alone the healthcare system. We are not biochemical experts, but we will also never be full-fledged comprehensive caregivers.



It’s silly and naïve to want to do everything…

…but it’s a difficult sentiment to avoid when you yearn to see how everything relates. In some ways, going to medical school after a liberal arts background feels like an incredible jump toward specialization, but in others respects I sense that many of us here still feel “too broad.” It’ll be a while yet before my cohort chooses clinical specialties, but you can begin to see people having fleeting fancies.

Of course, there is also the more general sense of the term “general” when applied to skills. You have to know who you’re working with, how to get through to people, and how the systems are fitting together. Know something about public health issues3 and epidemics; maybe even dip your toe in the political issues4 surrounding healthcare delivery. Maybe its actually good for doctors to be interested in this stuff...or maybe it just serves as a proxy for general intellectual curiosity. Maybe what we really care about most in our doctors (and teachers, friends, etc.) is that they want to keep learning and keep improving. There are a lot of intangible skills that don’t get tested, per se, before you move on to higher education. 

In theory, I like the idea of a well-rounded physician, but let’s face it: if the best heart surgeon in the world has no friends or family, I still want him to do my operation. When I seek medical care myself, I want a doctor who will listen, but also one who knows their stuff. No one’s people skills will make up for a depth of scientific knowledge (though they can certainly enhance it).



All of the things. I want to do ALL OF THE THINGS. 

Doctors are not always practicing medicine in the hospital, but also doing research, teaching, managing, consulting, etc. Earlier this spring, Charles Bosk, a medical sociologist, reminded me that “you learn to ice skate in the summer and you learn to swim in the winter.” He is a brilliant man, and our conversation wandered for quite some time; it left me feeling simultaneously excited and overwhelmed. We focused on issues related to career choices, but I thought later about how the same principles apply to our athletics, our relationships, and countless other things. A friend and I talked about how we want to run faster 10k races and also one day do a marathon, but no one can ever really excel at both since training faster and training longer are two different things (let alone the fact that this means we are setting aside swimming, dance, soccer, and our other previous endeavors). Likewise, with relationships, you sometimes have to choose between deepening the friendships you have and reaching out to new people. Trivial as it may be, its a little disconcerting that every minute we spend on one thing is one that we are not spending on another.

To a certain extent, it’s true that you approach problems in different ways if you’ve had experience in other realms. I worry, though, that when we spread ourselves too thin we end up mediocre in many things and really good at none of them. I probably spend too much energy thinking about these things and not enough energy making changes based on my reflections5. What do you think about breadth versus depth? Is that even a legitimate question?


1 I’m fully aware that – technically speaking – it’s not a dichotomy if these categories can overlap. Let’s just go with it, because I really like the word “dichotomy.”
2 I not-so-secretly miss college chalk boards and arrow-pushing in organic chemistry class, and I realized the reason I very secretly loved physical chemistry was that it was just all applied calculus.
3 In 5th grade, we had to do a report on a societal issue; there were about ten reports called “Global Warming,” but mine was called “Meth Labs.” So that was fun.
4 [cue gasp here]
5 read: overly-analytical-and-generally-unproductive ruminations

Friday, February 22, 2013

The nurse is always right, the patient is always right, and the patient’s mother is always right




Listen

A brilliant physician shared his wisdom with me during our most recent clinical training session. He was humble and inspiring, telling stories of patients who came in and practically diagnosed themselves. In a cautionary tone he reminded us that “the nurse is always right, the patient is always right, and the patient’s mother is always right.”

Listening skills are as valuable as anything else we develop over the course of our professional and personal lives. It’s not just for medical students and it’s not just for doctors. I can’t think of any role in my own life it doesn’t apply to, be it teacher, sister, friend, etc.



Think about it, and don’t necessarily respond

When someone comes to you and says they need advice, it’s quite likely they already know the answer but need to talk through it. Sure, there are times they genuinely want a second opinion; I absolutely appreciate the candid of advice of friends now and again. More often, though, they’re not asking you to talk (even if they say “can we talk about this?”). Rather, they are asking you to patiently listen as they explain all the complexities that they needed to verbalize before making a decision on their own. The best career counselors (and tutors/therapists/you-name-its) are not the best at giving prescriptive advice; they are the best at asking questions.



What are the right questions?

Good question. I don’t know; it depends…? We can grab for the obvious answers such as “use open-ended questions to elicit more of a story,” but there is a whole lot of subtlety to question crafting that can’t be quantified or listed. Scary things happen when we only ask questions we think we know the answers to, or when we purposefully ask leading or convoluted questions. Of course, leading questions are often unintentionally so; I find myself accidentally saying things laden with assumptions all the time (which then leaves me with the simultaneously awkward and terrifying fact that there are sure to be a million other times when I’m making assumptions and NOT ever realizing it).



Okay, that’s enough talking for today. What kinds of questions do you ask? When is it hardest to listen? Why do we filter what we hear?

Monday, January 28, 2013

Step into your Discomfort Zone


We all get uncomfortable – physically, socially, and intellectually. I’d venture a guess that even the most obscenely confident people occasionally find themselves in their Discomfort Zone. What I’m interested in talking about today are the intellectually painful challenges, the ones that push you to think in ways you’ve never thought before. There are the obvious trite analogies about forcing yourself into uncomfortable situations as a means to an end (e.g. training intensely for a marathon, undergoing repeated exposure therapy for arachnophobia, etc.). On some level, I think these analogies hold, to the extent that academic endeavors can be trying on an emotional and physical level, and yet I am inclined to say that there is something uniquely challenging about intellectual discomfort. I’m not sure quite why this is, and would love to hear your thoughts, but it seems more personal somehow. 
 

There’s something particularly irksome about things you can’t understand

My own first experience with intellectual discomfort came in the second grade, after I read a book on astronomy. When you think for a long time about the solar system, and then the galaxy, and then the universe, you reach a point when you start to think “…well THEN what?” I went through a phase where I would literally lie awake at night wondering where it ended and – once it ended – what was after that. Human brains are not wired in a way that comprehends endlessness. It still bothers me that my brain will never truly understand infinity.



I’ve also spent a fair bit of time pondering the ways in which different people perceive things like colors. My thoughts on this are aptly summarized in one of the many brilliant footnotes in David Foster Wallace’s “Authority and American Usage”:

“…the adolescent pot-smoker is struck by the ghastly possibility that, e.g. what he sees as the color green and what other people call “the color green” may in fact not be the same color-experience at all: the fact that both he and some else call Pebble Beach’s fairways green and a stoplight’s GO signal green appears to guarantee only that there is a similar consistency in their color-experiences of fairways and GO lights, not that the actual subjective quality of those color-experiences is the same; it could be that what the ad. pot-smoker experiences as green everyone else actually experiences as blue and what we “mean” by the word blue is what he “means” by green ...”


(N.B. I think it is totally legitimate to have these thoughts even if you are not an adolescent or a pot-smoker. I also think this is somehow analogous to the limits of empathy; we should recognize that we never completely understand what it’s like to be in someone else’s shoes.)

I deal with the problem of infinity and the problem of green in the most mature way possible: I ignore them. However, it would seem that most issues in life DO need to be dealt with, even when it is very, very uncomfortable.


Things you simply don’t know vs. things you don’t even know how to know

Let’s take a moment to explicitly distinguish this feeling of helplessness and incomprehension from the more common feelings of embarrassment and failure. Embarrassment can easily stem from simple ignorance, but it often reveals some gap in your knowledge that you can fix. (My first embarrassing moment in memory was at age three-and-a-half, in preschool, when I told my teacher that I knew how to close the Cheerios box, but then neglected to properly use the slit and tab.) It ranges anywhere from awkward to terrifying to be surrounded by people who are experienced and brilliant…but it is also thrilling! I love being around inspiring people who have so much to teach, especially when it seems they will talk about the type of thing I might one day be capable of learning. It’s not all that complicated to exchange feelings of inadequacy for those of excitement. 


It’s also okay to enjoy being good at things; no shame in that

Everyone likes to sit down to practice piano and play the songs they already know. It feels good, it sounds good, it pleases you, and it pleases others. And, on the flip side, you don’t really want a lot of people listening and watching the first time you try that new song. There is a certain amount of time everyone devotes to perfecting what they already do well because it’s fun to do things well and – admit it – positive feedback from others plays no small role. It can prevent you from trying new things, though, if you subconsciously settle.



New experiments

Lots of what we learn does not actually fit with the idea we started with – that of “intellectual discomfort.” Much of the newness we encounter follows the predictable course of frustration, embarrassment, failure, and then eventually learning. There are certain times it’s acceptable to “fake it ’til you make it,” but there are also times it’s understandable to let others know you need help (professionally, academically or personally). Who knows? Maybe they were faking it, too! Pretending to know what you are doing is an excellent strategy in many respects…until it prevents you from stepping back to realize that other people might, in fact, have a better way of getting it done. On a more serious note, there are times it is patently NOT okay to fake it. There is the immediately horrifying example of doctors making up answers when patients or colleagues ask questions they do not know how to answer, but we could come up with countless other situations in which it is just plain wrong to pretend.


The difference between ignorance and the Discomfort Zone

It is uncomfortable to feel stupid and arguably much, much more uncomfortable to be presented with something you think you’ll never master. I think what I’m trying to get at is this idea of frustration with our limits and why it might somehow still be worthwhile to push them, walking out to the edge, hating every second and thinking we’re going to fall right off. Why exactly might it be good to wrestle with certain intellectual dilemmas? For starters, maybe some of those impossibly incomprehensible things actually start to make sense (but please don’t waste your time with infinity or green…it’s a lost cause). Beyond that, though, it’s good to remember how pathetically little we actually know. It’s good to learn to be comfortable with – and even excited by – our weaknesses. We can make it an active decision; we don’t have to be “pushed out of our comfort zone.” Does it make it any more enjoyable to frame it as “stepping into your Discomfort Zone”? Perhaps not. Is it on some level more palatable? Maybe. You’ll have to test the waters.